Cytoskeleton 3d Model. Gmpcpp microtubule cell 2015 119 views 0 comment. Subscribe subscribed unsubscribe embed share report collection report collection ptx and microtubule.
Upon treatment with pharmacological agents that disrupt the cytoskeleton our model indicates that τ is decreased and matrix remodeling and traction forces in 3d are significantly diminished. The cytoskeleton organizes other constituents of the cell maintains the cell s shape and is responsible for the locomotion of the cell itself and the movement of the various organelles within it. Microtubules microfilaments actin filaments and intermediate filaments.
Characterized a novel 3d in vitro model of multicellular cancer cell invasion that offers adjustable physiological and biochemical parameters.
Shortcomings of current models are poor microscopic imaging dynamics and inability to study transmigration of cancer cells across the basement membrane bm and then invasion of an extracellular matrix ecm as happens in vivo. Recently guzman et al. Shortcomings of current models are poor microscopic imaging dynamics and inability to study transmigration of cancer cells across the basement membrane bm and then invasion of an extracellular matrix ecm as happens in vivo. Microtubules microfilaments actin filaments and intermediate filaments.
